Doktorand (PhD) in Molecular Medicine and Gene Therapy - Hiring in process/Finished, not possible to apply

The division of Molecular Medicine and Gene Therapy announces an exciting PhD research project (Defining Regulators of Human Hematopoietic Stem Cells using CRISPR/Cas9 Gene Targeting) in the field of biomedicine and stem cell biology. The molecular principles regulating hematopoietic stem cells (HSCs) remain incompletely defined. The overall aim of this thesis project is to develop paradigms for CRISPR mediated gene editing in primary human HSCs and to further employ these paradigms to target human HSCs in global functional screens to identify novel modifiers of proliferation and self-renewal. The findings may be implemented in targeted approaches to develop expansion of hematopoietic stem cells for clinical benefit.

Work duties
- Take part of the laboratory work connected to the project
- Writing articles and publications together with the supervisors at the laboratory
- Method development for the project
- Participation in the teaching of practical courses in the Research School and be involved in the teaching of master students in the lab
- Participation in relevant seminars and workshops
- Some administrative duties
- Take part of the doctoral courses provided by the Department and the Faculty

Work with experimental animals is included. 

Qualifications
The applicant must be a highly talented and motivated individual, and hold knowledge and documented experience in the field of biomedicine, stem cell biology and gene editing. Moreover, the student should have documented knowledge and practical experience in cell culture and molecular biology techniques.

Qualifying merits
Prior experience in laboratory work using human hematopoietic stem cells, flow cytometry and CRISPR/Cas9 gene editing is especially qualifying

Emphasis will be put on personal suitability. 

Eligibility
Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment
Limit of tenure, four years according to HF 5 kap 7§.