PhD student in Biomedicine - Hiring in process/Finished, not possible to apply

The increasing prevalence of type 2 diabetes in western societies is closely associated to sedentary life-styles, excessive consumption of hyper-caloric food products and obesity. Metabolic imbalances and diabetes impact the central nervous system (CNS). In this context, the initial events contributing to the loss of metabolic control involve derangements of hypothalamic function, and long-term metabolic imbalance contributes to brain dysfunction. Our lab is interested in the prevention of metabolic and functional alterations that occur in the CNS, with particular focus on rescuing the control of energy homeostasis, and on the recovery of cognitive ability.

The “Diabetes and Brain Function” lab is looking for a doctoral student to investigate the impact of diabetes on cerebral metabolism and function, with particular focus on neuron-glia interactions.

Work duties

This project aims at defining the mechanisms involved in the development of neurodegeneration and neuroinflammation in obesity-related diabetes, leading to brain dysfunction. In addition to identifying the involved molecular pathways, morphological and functional changes will be monitored non-invasively with magnetic resonance imaging and behaviour experiments.

Qualifications

Requirements

• Master degree in Biochemistry or similar subject
• Previous practical experience with rodent models of diabetes and Alzheimer’s disease
• Experience with proteomics, Western Blot, Dot Blot and/or immunohistochemistry analyses, real-time PCR, as well as with behaviour experiments
• Experience on investigating neurodegeneration and neuroinflammation
• Good knowledge of neurophysiology
• Good English language skills

Merits

• Understanding of neuroimaging methods
• Research experience abroad

Eligibility
Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment
Limit of tenure, four years according to HF 5 kap 7§.