Postdoctor in translational cancer research - Hiring in process/Finished, not possible to apply

The division of Translational Cancer Research and the laboratory of Chris Madsen is looking to hire a post doc. The main focus of the group, is to try to understand how cancer spreads through the body (a process called metastasis) as this is responsible for over 90% of cancer-related patient deaths. Metastasis is strongly influenced by the physical and chemical properties of the tumour microenvironment. The group studies how cancer cells move through this remodeled environment and aim at targeting intrinsic mechanisms of cancer cell motility as well as the mechanisms underlying the tissue remodeling. Our group use advanced microscopy to understand metastatic progression and tissue remodeling i.e. using 2-photon microscopy, multispectral optoacoustic tomography and ultrasound. We take a multidisciplinary, integrative approach to perform high quality translational cancer research with collaborative partners world-wide.

Work duties
The post doc will undertake work to validate a new anti-metastatic drug candidate in breast cancer. The project will cover both in vitro and in vivo experimentation and have two major aim: 1) peri-nuclear cytoskeletal re-organization during cell migration in confined environments and 2) peri-cellular matrix degradation during cancer cell migration and metastasis of breast cancer. The post doc will also help to develop specific matrix-degradation probes for the application of multispectral optoacoustic tomography (MSOT) imaging, a non-invasive whole animal imaging modality. This part will be in tight collaborations with other researchers of the group. Moreover, the postdoc will co-supervise and be responsible for the practical training of students in our group, and be in charge of the practical training and guidance of our fluorescence imaging platform. The postdoc will also actively collaborate with scientist outside the field of biology incl. nanotechnology and physics.

Requirements

• A PhD in Natural Science (physical or life science) or Medicine
• Documented experience with animal tumour models
• Documented experience with basic biochemical and molecular biology assays
• Documented experience with real time imaging using confocal microscopy
• Documented experience with reflectance microscopy
• Documented experience with high content screenings
• Documented experience with 3D cell migration analysis in high resolution
• Documented experience with work on the cytoskeletal network
• Documented experience with matrix degradation assays and MMP activity assays
• Documented experience with cloning and CRISPR technology

Meritorious

• Knowledge of general cytoskeletal regulation i.e. RhoGTPases etc.
• Knowledge of microfluidics and nanotechnology
• Excellence in statistical analysis

Personal characteristics
The postdoc applicant needs to be a motivated individual with high level of independence. The individual must be confident with a high degree of leadership responsibility and future leadership training. The applicant must be fluent in English, both in written and oral presentation. We therefore are very pleased if the application is submitted in English.

Emphasis will be held on personal suitability.