Postdoctor within translational cancer research - Hiring in process/Finished, not possible to apply

The division of Translational Cancer Research and the laboratory of Chris Madsen is looking to hire a post doc. The main focus of the group, is to try to understand how cancer spreads through the body (a process called metastasis) as this is responsible for over 90% of cancer-related patient deaths. Metastasis is strongly influenced by the physical and chemical properties of the tumour microenvironment. The group studies how cancer cells move through this remodeled environment and aim at targeting intrinsic mechanisms of cancer cell motility as well as the mechanisms underlying the tissue remodeling. Our group use advanced microscopy to understand metastatic progression and tissue remodeling i.e. using 2-photon microscopy, multispectral optoacoustic tomography and ultrasound. We take a multidisciplinary, integrative approach to perform high quality translational cancer research with collaborative partners world-wide.

Work duties
The post doc will undertake work to validate new regulators of mechanotransduction and mechanobiology in cancer, vascular disease and in mesenchymal stromal cell differentiation. The project will cover both in vitro and in vivo experimentation and have three major aims: 1) to characterize the molecular mechanism by which a new regulator of mechanotransduction is controlled 2) to validate the findings in vivo using animal models of cancer and 3) to validate the potential in regenerative medicine and differentiation of stem cells. Moreover, the postdoc will co-supervise and be responsible for the practical training of students in our group, and be in charge of the practical training and guidance of all work related to stromal and mesenchymal differentiation. The postdoc will also actively collaborate with scientist outside the field of biology incl. nanotechnology and physics.

Requirements

• A PhD in Natural Science (physical or life science) or Medicine
• Documented experience with animal models of cancer 
• Documented experience with animal models of regenerative medicine
• Documented experience working with stromal cells including fibroblasts, MSCs, endothelial cells etc
• Documented experience with basic biochemical and molecular biology assays
• Documented experience with cloning and CRISPR technology
• Documented experience with flow cytometry and FACS sorting
• Documented experience with fluorescence microscopy
• Documented experience with stem cell differentiation assays
• Documented experience with mechanobiology and mechanotransduction
• Documented experience with 3D cell culture methods

Meritorious

• Knowledge on stromal cell purification from in vivo models using FACS sorting 
• Knowledge on matrix stiffness and stem cell regulation
• Excellence in statistical analysis

Personal characteristics
The postdoc applicant needs to be a motivated individual with high level of independence. The individual must be confident with a high degree of leadership responsibility and future leadership training. The applicant must be fluent in English, both in written and oral presentation. We therefore are very pleased if the application is submitted in English.

Emphasis will be held on personal suitability.