Research engineer in RNA and Stem Cell Biology - Hiring in process/Finished, not possible to apply

The laboratory of RNA and Stem Cell Biology is embedded within the Lund Stem Cell Center, an internationally ranked research center within the strategic areas of Stem Cell Biology and Regenerative Medicine at Lund University, Scandinavia’s largest institution for education and research. Our research focuses on new post-transcriptional facets of gene expression control in stem and cancer cell at a molecular, cellular and organismal level. Specifically, we are interested in the molecular basis by which RNA modifications regulate gene expression in during development and in cancer.

Work duties and areas of responsibility

The overarching goal of the project is to study the function of RNA modifying enzymes in stem and cancer cells. Our laboratory has recently discovered new roles for RNA pseudouridine modifications in control of small RNAs impacting protein synthesis and stem cell differentiation. The specific aims are: (1) characterize the molecular machinery responsible for biogenesis and function of stem cell- associated small RNAs, (2) unravel regulatory pathways governing specific RNA pseudouridine synthases in stem cells and (3) study the effects of altered RNA modification in human embryonic and hematopoietic stem cells.

Qualifiations - requirements

The applicant should hold a M.Sc. in Biomedical Genetics, Biochemistry or equivalent. Applicants should have previous experience with protein production, RNA work (in vitro transcription, radiolabeling, EMSA, primer extension, northern blotting), standard molecular biology techniques (e.g. cloning, RT-qPCR, gel electrophoresis, western blotting) and cryo-electron microscopy. Applicants are expected to work independently as well as part of a research team. Excellent verbal and written English communication skills are required.

Qualifications - desirable

Expertise with crystallographic data collection and macromolecular crystallization screening is highly preferred. Successful applicants should possess the capacity to improve established models, protocols and/or develops new methods.

Emphasis will be held on personal suitability.