Postdoctor in RNA and Stem Cell Biology - Hiring in process/Finished, not possible to apply

The laboratory of RNA and Stem Cell Biology is embedded within the Lund Stem Cell Center, an internationally ranked research center within the strategic areas of Stem Cell Biology and Regenerative Medicine at Lund University, Scandinavia’s largest institution for education and research. Our research focuses on new facets of gene expression control in stem and cancer cell at a molecular, cellular and organismal level. Specifically, we are interested in the molecular basis by which RNA modifications regulate gene expression in during development and in cancer.

Work duties and areas of responsibility

The overarching goal of the project is to study the function of RNA modifying enzymes in stem and cancer cells. Our laboratory has recently discovered new roles for RNA pseudouridine modifications in control of small RNAs impacting protein synthesis and stem cell differentiation. The specific aims are: (1) characterize the molecular machinery responsible for biogenesis and function of stem cell- associated small RNAs, (2) unravel regulatory pathways governing specific RNA pseudouridine synthases in stem and cancer cells and (3) study the in vivo effects of altered RNA modifications.

Requirements

The following qualifications are required for the position:

• A PhD in Biochemistry or equivalent.
• Previous experience with protein production, RNA work (in vitro transcription, radiolabeling, EMSA, primer extension, northern blotting), standard molecular biology techniques (e.g. cloning, RT-qPCR, gel electrophoresis, western blotting), protein crystallography, mass spectrometry and cryo-electron microscopy.
• The ability to work independently as well as part of a research team.
• Excellent verbal and written English communication skills.

Applicants’ personal suitability to work within our research environment will be also considered.

Desirable

The following qualifications are desired for the position:

• Expertise with macromolecular crystallization screening is highly preferred.
• The capacity to improve established models, protocols and/or develops new methods.
• Certified qualification for laboratory animal science research in accordance to the EU legislation.