PhD in clinical genetics - Hiring in process/Finished, not possible to apply

Research group
The research group focusing on pathways of cancer cell evolution is looking for a PhD student to the PhD project 'Phylogenetic analysis of pediatric cancer'. The research group is lead by professor David Gisselsson-Nord. 

The group focuses on genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. In particular, they aim to: 1. Make phylogenetic maps of cancer cell variation over anatomic space and treatment time in order to understand the conditions leading to treatment resistance; 2. Assess the functional effect on the RNA and protein levels of genetic variation in tumours; 3. Analyze to what extent clinical biomarkers exhibit variability within a tumour lineage – a potentially important source of error in clinical decision making; 4. Evaluate the potential of using parameters of genetic variation as biomarkers for response to treatment. To reach these aims they use a combination of traditional histopathology and next-generation sequencing technologies. The group works on three of the most common solid tumours in children: neuroblastoma, Wilms tumour and rhabdomyosarcoma.

Work description
This project will refine methods from species evolution (phylogenetics) to trace the origins of treatment resistance pediatric cancers.

The work duties are connected to the PhD project and the PhD studies at the faculty of Medicine. Other common work duties related to the lab is also applicable. 

Eligibility
Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

• Experience through a degree project or equivalent of programming applied to phylogenetic analysis of copy number aberrations in pediatric cancers is highly meritorious. 

Type of employment
Limit of tenure, four years according to HF 5 kap 7§