Lund University, Faculty of Science, Department of Chemistry

Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has 40 000 students and more than 8 000 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

The Faculty of Science conducts research and education within Biology, Astronomy, Physics, Geosciences, Chemistry, Mathematics and Environmental Sciences. The Faculty is organized into nine departments, gathered in the northern campus area. The Faculty has approximately 1500 students, 330 PhD students and 700 employees.

The Division of Biochemistry and Structural Biology forms, together with the Division of Biophysical Chemistry, the Centre for Protein Molecular Sciences (CMPS) at the Department of Chemistry, Lund University. The research at CMPS aims to understand the molecular mechanisms of cellular processes by exploring structure, dynamics and function of key proteins in a highly integrated approach.

The advertised postdoc position will be placed in the group of Prof. Susanna Törnroth-Horsefield who focuses on structural and functional studies of integral membrane proteins and membrane protein complexes using an integrative structural biology approach, combining structural determination by X-ray crystallography, cryoEM and small angle scattering with biophysical protein characterization methods. The work will be part of a collaborative project with groups at Uppsala University, Hamburg University and the European XFEL that aims to develop a novel method to carry out serial protein crystallography using fixed sample delivery systems.

Job description
The aim of the postdoc project is to carry out structural studies of membrane protein complexes using a combination of conventional crystallography and serial crystallography. Specific tasks include:

  • Overproduction of soluble and membrane proteins
  • Biophysical characterization of protein-protein interactions
  • Crystallization of membrane protein complexes
  • Data collection at synchrotrons and FELs
  • Structural determination by X-ray crystallography

The postdoc is expected to take an active part in the overall research activity of the group, including sharing duties in the laboratory and responsibility for equipment as well as co-supervision of PhD- and undergraduate project students.

Qualifications
The successful candidate must have a PhD in Structural Biology, Biochemistry, Biophysics, Medicine or related area. Previous experience in membrane protein production in eukaryotic cells, membrane protein purification, and crystallization as well as characterization of membrane protein-protein interactions is required.
The successful candidate must be able to work independently. This includes the ability to suggest, plan and excecute relevant experiments as well as interpret, present and discuss results in an independent manner. The successful candidate must also be able to work collaboratively in a research team. The candidate must be proficient in the English language, both for everyday and scientific communication, and have a documented ability to present research in a clear manner, both as oral presentations and in writing in the form of scientific articles.

Meritorious
The following is considered a merit for the position:

  • Previous experience in synchrotron data collection on protein crystals.
  • Previous experience in using microscale thermophoresis for characterization of protein-protein interactions involving membrane proteins.
  • Documented experience in supervising project students.
  • Documented ability to attract independent funding for travel or research.

Other
The work includes international travel to synchrotrons and FELs for experiments as well for project meetings and conferences. The position is for 2 years with expected start during the autumn 2020.

Terms of employment This is a full-time, fixed-term employment of a maximum of 2 years. The period of employment is determined in accordance with the agreement “Avtal om tidsbegränsad anställning som postdoktor” (“Agreement on fixed-term employment as a post-doctoral fellow”) between Lund University, SACO-S, OFR/S and SEKO, dated 4 September 2008.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment 2020-11-01
Salary Monthly salary
Number of positions 1
Working hours 100%
City Lund
County Skåne län
Country Sweden
Reference number PA2020/2972
Contact
  • Susanna Horsefield, Senior lecturer, +46462224584, susanna.horsefield@biochemistry.lu.s
  • Magdalena Brossing, HR coordinator, +46 46 222 95 62
Union representative
  • OFR/ST:Fackförbundet ST:s kansli, 046-222 93 62
  • SACO:Saco-s-rådet vid Lunds universitet, 046-222 93 64
Published 08.Oct.2020
Last application date 26.Oct.2020 11:59 PM CET

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