Associate Researcher in Cancer and Matrix Remodelling - Hiring in process/Finished, not possible to apply

The Research Group

The Division of Translational Cancer Research and the Department of Laboratory Medicine, led by Senior Lecturer Chris D. Madsen, is looking to hire an associate researcher. The main focus of the group, is to understand how cancer spreads through the body (a process called metastasis) as this is responsible for over 90% of cancer-related patient deaths. Metastasis is strongly influenced by the physical and chemical properties of the tumour microenvironment, and mechanosignalling has proved essential during metastatic dissemination. The person will undertake work to validate new regulators of mechanotransduction and mechanobiology in tissue remodeling and cancer progression. The project will cover both in vitro and in vivo experimentation and has three major aims: 1) to evaluate the importance of mechanosignalling in the primary tumour, 2) to evaluate how mechanosignalling in the primary tumour affects the local tumour microenvironment. 3) to test how recruitment of stromal cells can determining metastastic spread. Read more about our research here.

We are keen to safeguard a good work environment that allows for open discussions and where we care for each other’s well-being. We engage in equality work and consider differences to enrich our work place.

The research group is looking for an associate researcher to join our team. The employment is a full time position, time limited to 2 years, with the desired access date on April 1, 2021, or according to agreement.

Work duties and area of expertise

The candidate will undertake experimental work to examine how aberrant mechanotransduction is affecting tumour development. The project will cover both in vitro and in vivo experimentation. The associate researcher will develop various cell systems and mouse models to regulate mechanotransduction upon stimulation. The candidate will work with genome editing, lentiviral production, animal models of cancer, inflammation models in animals, and transgenic mouse models of cancer.

Qualifications

The position requires:

• A PhD in Natural Science (physical or life science)
• Postdoctoral experience in cancer and mechanobiology
• Documented experience with animal models of cancer
• Documented experience working with stromal cells including fibroblasts, MSCs, endothelial cells etc
• Documented experience with basic biochemical and molecular biology assays
• Documented experience with lentiviral work
• Documented experience with tissue collection, processing, staining and post-analyses
• Documented experience with fluorescence microscopy
• Documented experience with mechanobiology and mechanotransduction

Great emphasis will be placed on personal qualities. You must be able to work independently within the framework of major research collaborations. This places demands on responsibility, communication skills and openness.

The following are merits for the position:

• A PhD in Medical science would be desirable
• Knowledge on matrix stiffness and stem cell regulation
• Knowledge on stromal cell purification from in vivo models using FACS sorting
• Theoretical knowledge on cancer-associated fibroblasts
• Practical knowledge on culturing and working with cancer-associated fibroblasts
• Experience with cloning and CRISPR technology
• Excellence in statistical analysis
• The wish to become an independent researcher
• The wish to apply for own funding
• Strong knowledge in preparing and publishing high-impact papers

Instructions for your application

The application must contain a personal letter describing how you fulfill the desired qualifications, a CV and diploma.

Other

The position requires animal work, thus allergies towards animal could be an obstacle.

The university applies individual salary setting. Please indicate your salary claim in your application.