Researcher in Biomedical Engineering with focus on Biomechanics - Hiring in process/Finished, not possible to apply

Subject description

The biomechanics group's research is focused on understanding the link between mechanics and biology in the musculoskeletal system. More specifically, the research involves biomechanics, pathologies and repair of skeletal tissues using tissue characterisation methods, imaging, and computational simulation techniques. The research has direct applications in orthopaedics, where clinicians are looking for improved methods or understanding of repair of skeletal tissues, e.g. bone, cartilage, and tendons.

Osteoporosis is defined as low bone mass, and results in a markedly increased risk of skeletal fractures. The number of osteoporosis related bone fractures continuously increases. Development of new drugs to reduce bone loss or increase bone mass is promising. However, it requires that the individuals at high risk of fracture can be accurately identified. Current osteoporosis diagnostics is largely based on measurements of bone mineral density (BMD), using dual energy X-ray absorptiometry (DXA) of the hip or the lumbar spine. DXA-based BMD is only a moderate predictor of fracture risk. Novel methods that account for all characteristics of the bone and their influence on the bone’s resistance to fracture are needed.

The aim of the research is to improve osteoporosis diagnosis and fracture risk assessment by introducing a mechanistic prediction of bone strength based on three-dimensional finite element analysis (FEA), while keeping DXA as the standard screening technique. This can be accomplished by combining DXA imaging with a 3D reconstruction based on a shape template and a statistical description of bone variance within a population.  A method to estimate the 3D geometry of the hip bone based on a 2D image and a shape template is available, and its ability to predict bone strength in a single-leg-stance configuration has been shown promising.  The project should determine the ability to predict bone strength and evaluate the ability of the method to predict fracture risk in population-based studies.

Work duties

The main duties involved in a research posistion is to conduct research.

The work duties include:

• image analysis and numerical modelling
• experimental mechanical testing, imaging, and digital image correlation
• data analysis
• supervision of MSc degree projects and assisting in supervision of doctoral students
• actively seeking external research funding
• actively participate in the project-related national and international collaborations
• administration related to the work duties

 Qualification requirements

Applicants must have:

• a PhD or equivalent research qualification
• very good oral and written proficiency in English
• a background in engineering wtihin (bio)mechanics
• the ability to independently drive research projects of high quality
• documented experience of writing scientific publications
• experience with multidisciplinary projects

Assessment criteria and other qualifications

• a strong background in bone mechanics, finite element modelling, and image analysis and mechanical testing
• experience in statistical shape modelling and reconstructions of bone
• experience in applying for external funding
• international networks and experience

International experiences and networks are also considered positive.

Consideration will also be given to good collaborative skills, drive and independence, and how the applicant’s experience and skills complement and strengthen ongoing research within the department, and how they stand to contribute to its future development.

Terms of employment

Permanent position, 100 %

Instructions on how to apply

Applications shall be written in English. LTH uses a special qualifications portfolio to report and document qualifications. Draw up the application in accordance with the following outline and attach it as three PDF files (in the recruitment system). Read more here: http://www.lth.se/index.php?id=71223