PhD Student in Clinical Genetics - Hiring in process/Finished, not possible to apply

The Research Group

Professor Kajsa Paulsson leads the research group Aneuploidy in Cancer at the Department of Clinical Genetics at the Faculty of Medicine. We are studying the biology of acute leukemia using large-scale genomics and bioinformatic methods. We aim to understand how different types of genetic aberrations cause development of leukemia in order to improve treatment and survival in pediatric acute leukemia. Read more about our research here. 

Within the research group, we cherish an activity that aims to create a creative and stimulating work environment to promote new ideas and independent thinking.

We are hereby looking for and driven doctoral student who will work in the doctoral project "Non-coding mutations in pediatric acute lymphoblastic leukemia ". The employment is limited to 4 years on a full-time basis with the desired date of entry on 1 September 2021 or by agreement.

Work duties and area of expertise

The aim of the project is to elucidate how non-coding cis-regulatory variants affect the leukemogenesis of childhood acute leukemia. The study will include the identification of novel recurrent genetic events, studies of their effect on leukemogenesis, and clinical-genetic correlations. Tasks will largely include computational analysis of whole genome sequencing, RNA sequencing and SNP array data but will likely also include substantial functional analyses of cell lines and introduction of mutations by CRISPR-CAS9 into cell lines. Other existing tasks within the research group may also be included.

In addition to following the doctoral program, as well as participating in relevant courses for the education, the position also includes the following tasks:

• Maintaining a lab book and similar administrative tasks
• Compiling and interpreting results, certain bioinformatics included
• Writing scientific articles for publication

The doctoral student must actively participate in seminars and other important meetings and present the project at meetings in accordance with the study plan. The doctoral student has his or her own responsibility to:

• Seek contact with the colleagues who best support a discussion about the results
• Find ways for career support
• Formulate, develop and optimize the ways for communication with supervisors and colleagues that best promote the doctoral student's work methods and qualifications

Qualifications

The position requires:

• MSc degree in a relevant area (e.g. biomedicine, biotechnology, molecular biology, bioinformatics)
• Documented experience from programming in a Linux/ Unix environment (e.g. Perl/Python/R)
• English skills level B1/B2: Independent user
• Very good writing and reading comprehension

Great emphasis will be placed on personal qualities. The successful applicant is curious and has good problem solving skills. It is required that you have a good communicative ability and are good at collaborating. In addition, the tasks require that you are organized and have the ability to prioritize your tasks.

Desired merits for the position is:

• Documented experience of next generation sequencing data analysis and statistics in the cancer research field
• Documented experience from cancer research

Instructions for the application

The application must contain a personal letter in which you describe how you meet the desired qualifications, a CV and diploma.

Eligibility
Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment
Limit of tenure, four years according to HF 5 kap 7§.