Doktorand (PhD student) within the field of Leukemia - Hiring in process/Finished, not possible to apply

The Research Group

Researcher Charlotta Böiers leads the research group Developmental Lymphopoiesis and Leukemia at the Division of Molecular Heamatology at the Faculty of Medicine. The research group focuses on Acute Lymphocytic Leukemia (ALL), which is one of the most common cancers in children. An unanswered question in cancer in general is in which cell the process starts. ALL in children provide unique opportunities to study this as the mutation that comes first is often known and in several cases has been shown to occur already during fetal life.

The goal of the project is to study leukemia with a focus on how the disease is initiated. We use pluripotent stem cells to model leukemia and study how mutations affect otherwise normal cells biologically and molecularly. Read more about our ongoing research here.

Within the research group, we strive to create a creative and stimulating work environment and to promote new ideas and independent thinking.

We are hereby looking for an ambitious doctoral student who will work in the doctoral project "Modelling B cell leukemia using pluripotent stem cells". The employment is limited to 4 years on a full-time basis with the desired date of entry on 1 December 2021.

Work duties and area of expertise

In addition to following the study plan for the doctoral program, and participating in relevant courses for the program, the work tasks also include cell culture work with a focus on pluripotent stem cells and differentiation of these towards different cell types, in vitro cultures and analyzes with flow cytometry and cell sorting. The work tasks also contain molecular methods such as genotyping, RNA sequencing, ATAC seq - depending on what the project requires - and work with bioinformatics and analysis of molecular data. Other tasks may occur depending on what the project requires.

The doctoral student must actively participate in seminars and other important meetings, present the project at meetings in accordance with the study plan and maintain a lab book and similar administrative tasks.

Qualifications

The position requires:

• Degree within a relevant field, 240 credits or more, or equivalent foreign degree
• Very good writing and reading comprehension
• Very good English in speech and writing

Great emphasis will be placed on personal qualities. The successful applicant takes initiatives and is independent. It is required that you are good at collaborating. In addition, the PhD studies and the work tasks require that you are organized and have the ability to prioritize your tasks.

Desirable for the position is:

• Education in molecular biotechnology
• Experience of supervision / teaching in a relevant area
• Documented course / training in flow cytometry
• Practical experience of cell culture work
• Practical experience of working with human pluripotent stem cells
• Practical experience of molecular methods and RNA sequencing
• Practical experience of cloning

Other

Inconvenient working hours will occur.

Instructions for the application

The application must contain a personal letter in which you describe how you meet the desired qualifications, a CV and diploma.

Eligibility
Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment
Limit of tenure, four years according to HF 5 kap 7§.