Reserach engineer at the Department of Infectious Diseases

Description of the workplace

Lund University Hospital’s Clinic for Infectious Diseases is a hub of cutting-edge research and clinical expertise, where specialists like Adam Linder and the team at the Infection Medicine Proteomics (IMP) lab, led by Professor Johan Malmström, are dedicated to advancing mass spectrometry to understand the molecular mechanisms of bacterial infections and sepsis. This collaborative environment fosters innovative research in early diagnostics, new treatment options, and long-term outcomes, ultimately aiming to improve preventive, diagnostic, and therapeutic strategies for severe infections.

The project will be a collaboration between Drs. Adam Linder and Johan Malmström. The research project aims to develop a new approach to treating sepsis by focusing on disease tolerance instead of directly targeting the pathogen. The goal is to identify new therapeutic markers and understand the time windows for optimal treatment efficacy, which could lead to improved methods for treating sepsis.

Within the research group, we value a positive working environment with mutual respect and care in our relationships. We continuously work to create conditions for job satisfaction, development, and participation for all employees.

We offer
Lund University is a public authority, which means that employees get benefits, generous annual leave and an advantageous occupational pension scheme. Read more on the University website about being a Lund University employee:   Work at Lund university 

Work duties and areas of responsibility

As a research engineer, your duties will be divided into two main activities: Delineating mechanisms controlling tolerance by disrupting mitochondrial protein synthesis and defining treatment windows and characterizing the organ damage-limiting effects of tetracyclines in sepsis.

The following tasks will be performed:

• Preparation of mouse organ samples for proteomics-based characterization of various organs.
• Preparation of primary human neutrophils and monocytes for proteomics and metabolomics.
• Reading literature to find protocols to get a sense of how to prepare samples. Additionally, you will contact the Scilife lab metabolomics node in Umeå to obtain protocols from them for sample preparation and send the samples for MS analysis.
• Analyzing data using R scripts.

Qualifications

The following qualifications are required for the position:

• Master's degree in Biomedicine or equivalent.
• Background knowledge of inflammation, cell culture, microbiology.
• The ability to think critically and independently is highly valued.

Personal qualities we value highly in connection with this position are a high level of engagement, curiosity, and strong collaboration skills.

Additional qualifications for the position are:

• Education in immunology and microbial pathogenesis. A solid theoretical background in the various parts of the immune system, its development, regulation, and understanding of the mechanisms of bacterial infection.
• Basic knowledge of R scripts, molecular biology techniques, mesoscale analysis, microscopy, handling of blood samples, practical experience with immune cell culture, and experience with treatment effects related to inflammation.

Further information

The employment is a fixed-term employment (SÄVA) full-time for 6 months. Desired first day of employment is October 1st, or as agreed.

How to apply

You apply for the position via the University’s recruitment system. The application is to include a personal letter describing how you meet the qualification requirements and why you are interested in the position. The application is also to include a CV with a list of publications, a general description of previous research work, a copy of your doctoral degree and any other documents to which you wish to draw attention (copies of degree certificates, grade transcripts, details of referees, letters of recommendation, etc.)

Welcome with your application!