Research engineer in neuroscience

Description of the workplace

At the research unit for experimental dementia, research is conducted within/with the aim of understanding the mechanisms of pathogenesis sand means of improving translational research on dementias. The unit is headed by professor Gunnar Gouras.

We work to create a positive, respectful, and stimulating environment. We value communication and collaboration and our workplace that promotes learning and development for all employees. We are committed to building a safe and positive environment for all employees through mutual respect and tolerance.

Lund University is a governmental authority, which means you get special benefits, generous holidays and a favorable occupational pension. We also have a flexible time agreement that creates good conditions for a balance between work and leisure.

Read more on the university's website about being employed at Lund University, Work with us.

Work duties

This is a 75% position where your responsibilities involve doing injections of experimental therapies in mouse models of Alzheimer’s disease managing, including cisterna magna into brain and intraperitoneal injections The job main responsibilities also involve performing immunolabelling and microscopy quantification of brain sections. There likely will also be a role for the candidate to manage systems within the microscopy platforms for the Strategic Research Area MultiPark (Multidisciplinary Research environment on Parkinson’s disease and related disorders). T

In the role as research engineer you will work to better understand the mechanisms of immunotherapy as a treatment for Alzheimer’s disease, which will include specific brain surgical procedutres, cutting of brain section, immunolabelling and interpretation using microscopy. You might also be asked to contribute to tasks that include managing and maintaining one or more microscopes that are part of the Strategic Research Area MultiPark. This may include training of new users, maintaining a schedule of usage, troubleshooting and/or advising users.

You will implement methods to study alterations in pathologies in models of Alzheimer’s disease. For this, you will plan and carry out sample preparation of brain sections and relevant experiments. With the data obtained, you will perform data analysis and statistical analysis with which you will use when writing manuscripts. Other existing tasks within the research group may also become relevant.

The work is carried out on site in Lund.

Qualifications

For this position, you must have

• PhD in biomedical science relating to the topic of neuroscience
• Expertise with stereotactic injections into mice brains and good knowledge in research on Alzheimer’s disease
• Good knowledge and experience with light microscopy methods (epifluorescence and confocal)
• Documented experience with 3D image visualization and analysis
• Experience with tissue cutting/processing and immunohistochemistry/immunofluorescence
• Experience with quantifications of microscopy images
• Good knowledge of statistics
• Good knowledge of written and spoken English as well as experience in writing and publishing manuscripts
• Good organizational skills
• Good collaboration and support skills as well as the ability to work independently

Meritorious for the position are:

• Good knowledge of brain anatomy
• Experience of analyzing data related to Alzheimer’s models
• Experience using IMARIS and ImageJ software
• Experience in the analysis of amyloid and tau pathologies
• Experience using Zeiss, Leica and/or Nikon microscopy systems

Terms of employment

The employment is a special fixed-term employment (SÄVA) of 2 months, with scope 75%. Desired start date is February 15, 2025, or as agreed.

How to apply

The position is sought via the university’s recruitment system. Applications must include a personal motivation letter, in which you describe how you meet the qualification requirements and why you are interested in the position. The application must also contain a CV, contact information of two references, a diploma (including a grade transcript) and other documents you wish to be considered (e.g. letters of recommendation and list of publications).