Projectassistant in Biochemistry and Structural Biology

Work duties
Work within a project focused on studying interactions between chaperone proteins and amyloid proteins, producing and purifying these components, as well as selecting and analyzing binding proteins from large libraries. The tasks include, but are not limited to:

• Laboratory service, including preparation of solutions.
• Routine maintenance of FPLC systems.
• Protein expression in bacterial cells such as E. coli.
• Protein purification using ion exchange chromatography and gel filtration chromatography.
• Protein purification using affinity chromatography, such as the split-EF-tag system.
• Protein-protein interaction analysis on cell surface proteins using FACS.
• Yeast and bacterial display with FACS sorting.

 Qualifications

• Education: Master’s degree or equivalent in natural sciences.
• Documented practical experience in protein expression in bacterial cells.
• Documented practical experience in protein purification from cell extracts using ion exchange chromatography and gel filtration chromatography.
• Documented practical experience in handling automated chromatography systems such as FPLC and HPLC.
• Documented practical experience in servicing automated chromatography systems such as FPLC and HPLC.
• Documented practical experience in protein analysis using optical spectroscopy and dynamic light scattering.
• Skills: Fluent in Swedish and/or English.

 Other merits

• The candidate would preferably have experience in expression and purification of amyloid proteins and chaperones, including Aβ, Tau, α-synuclein, and DNAJB6.
• Experience in developing laboratory methods and reagents is considered an advantage.

We will place great emphasis on personal suitability. Consideration will be given to strong collaborative skills, drive, and independence, as well as how the applicant’s experience and expertise are assessed to complement and strengthen the laboratory work and contribute to its future development.

Terms of employment

A full time (100%) fixed-term employment will start 1st of March and until 31st of December 2025.

Contact person: Martin Lundqvist, martin.lundqvist@biochemistry.lu.se

Instructions on how to apply

Applications should include a cover letter stating the reasons why you are interested in the position and in what way the employment corresponds to your qualifications. The application should also contain a CV, degree certificate or equivalent, and other documents you wish to be considered (grade transcripts, contact information for your references, letters of recommendation, etc.).