Assistant Researcher at the Division of Cell Mechanobiology

Workplace Description
Our research group focuses on cellular and molecular mechanotransduction, with a particular emphasis on integrin signaling, mechanical cues from the extracellular matrix (ECM), 3D cultures, epithelial homeostasis, and nuclear mechanotransduction. We investigate how cells sense and respond to mechanical signals from their environment, particularly in the context of ECM remodeling, cancer invasion, and tissue homeostasis.

Our laboratory employs a combination of advanced fluorescence microscopy techniques, including super-resolution imaging (SIM), confocal microscopy, and live-cell imaging, CRISPR-based gene editing, and 3D biomaterial-based culture systems to study cell behavior in physiologically relevant models. We are part of an interdisciplinary and collaborative research environment, with access to state-of-the-art microscopy facilities, bioengineering platforms, and computational tools for image analysis.

The successful candidate will join a dynamic and supportive team and have the opportunity to collaborate with experts in biophysics, bioinformatics, and cancer biology to deepen the understanding of cell-matrix interactions in health and disease. Within our research group, we foster a positive work environment characterized by respect and care in our relationships with one another. We continuously strive to create conditions for job satisfaction, development, and participation for all employees.

What We Offer
Lund University is a public authority, which means that you will benefit from special employment conditions, generous holiday entitlements, and an advantageous occupational pension scheme. Read more on the university’s website about working at Lund University.

Job Description and Responsibilities
The assistant researcher will be responsible for conducting independent and collaborative research in cellular and molecular mechanotransduction, with a particular focus on integrin signaling, ECM remodeling, and mechanosensitive signaling pathways in epithelial homeostasis and cancer invasion.

Key responsibilities include:

• Designing and performing experiments using 3D biomaterial-based culture systems to investigate cell-ECM interactions.
• Utilizing advanced fluorescence microscopy techniques (including super-resolution imaging (SIM), confocal microscopy, and live-cell imaging) to study cellular responses to mechanical cues.
• Applying CRISPR-based gene editing to modify key genes involved in mechanotransduction and analyzing functional effects.
• Analyzing image data using quantitative image analysis and computational tools.
• Collaborating with other researchers within the laboratory and external partners in interdisciplinary projects.
• Contributing to manuscript writing, scientific presentations, and research grant applications.
• Participating in the supervision of doctoral students, as well as in lab meetings, journal clubs, and seminars.

The position offers opportunities for career development, networking, and training in advanced microscopy, bioinformatics, and mechanobiology.

Qualifications
Required qualifications:

• PhD in biomaterials, bioengineering, cell biology, molecular biology, or a related field.
• Strong expertise in cellular and molecular mechanotransduction, with experience in ECM remodeling and integrin signaling.
• Practical experience with 3D cell culture systems and biomaterial-based models.
• Proficiency in advanced fluorescence microscopy, including confocal microscopy and/or super-resolution imaging.
• Ability to work independently as well as collaborate effectively in an interdisciplinary research environment.
• Strong problem-solving skills, attention to detail, and excellent communication skills.

Desirable qualifications:

• Additional training in biophysics, mechanobiology, or bioinformatics for image analysis.
• Strong knowledge of quantitative image analysis and computational methods for microscopy data.
• Experience with live-cell imaging and high-content screening methods.
• Demonstrated ability to contribute to manuscript writing and scientific presentations.

Terms of Employment
This is a temporary SÄVA position for 12 months at 100% employment. The desired start date is April 1, 2025, or as agreed upon.
Employment at Lund University is based in Sweden; therefore, you are expected to perform your work on-site in Lund.

Application Instructions
Your application should include:

• A cover letter describing why you are interested in the project, how you meet the required qualifications (including previous independent projects and technical skills), as well as your research interests and future career plans.
• CV – including the names and contact details of two previous supervisors.
• Complete publication list (can be included in the CV).
• Copy of degree certificate (PhD diploma or equivalent).

We warmly welcome your application!