Associate researcher in translational single-cell genomics - Hiring in process/Finished, not possible to apply

Description of the workplace

The Center for Translational Genomics (CTG) is a prioritized research infrastructure at the Faculty of Medicine, Lund University, which is part of the Clinical Genomics platform at SciLifeLab (Scilifelab). The Clinical Genomics platform offers state-of-the-art genomics-based services (e.g. novel single-cell applications) to translational and clinical researchers across Sweden as a whole and promotes rapid translation of new research findings into clinical utility through close collaborations with the regional healthcare providers. The unit is localized at BMC D14 in Lund and currently consists of a multi-disciplinary team of 14 people.

We are now looking for a highly driven, experienced and team-oriented associate researcher, interested in developing and providing cutting-edge research services in single-cell and spatial biology sequencing applications. As a workplace, we safeguard a positive work environment with respect and consideration in our relations with one another.

Work duties and responsibilities

You will become a part of a highly dedicated and experienced team, focused on providing innovative research services in single-cell and spatial biology sequencing applications. As these methodologies constitute a national technology focus area (TFA) within the SciLifeLab Clinical Genomics platform, led by CTG, you will also contribute to the impact of CTG nationally.

The work duties will include practical work on the latest single-cell and sequencing platforms (e.g. NextSeq 2000, NovaSeq X Plus). The role also includes continuous improvement and standardization of existing analysis methods (e.g. single-cell applications, basic histology and microscopy), advisory meetings with researchers or other users of the facility in association with different types of service and development projects as well as administration of service projects. The work will be highly team-oriented, both through internal and external collaborations, which necessitates excellent collaboration and communication skills.

The main work duties are:

• Performing state-of-the-art single-cell sequencing experiments on different commercial platforms (e.g. 10X Chromium/ChromiumX, Visium CytAssist, Xenium, CellenONE F1.4)
• Development and implementation of new methods for NGS-based single-cell and spatial tissue analyses
• Basic light and fluorescence microscopy of tissue sections (e.g. Nikon Ti2)
• Providing expertise and advice to researchers and other facility users in connection with different service and development projects (single-cell and spatial tissue analysis)
• A variety of administrative tasks, such as documenting and reporting of service activities, procurement of expensive instruments as well as scientific writing.

Qualifications

The requirements for the position are:

• Adequate university degree (e.g. MSc in molecular biology, biomedicine or equivalent)
• PhD from relevant research field (i.e. molecular biology, genomics or equivalent)
• Very good knowledge about, and documented practical experience of, work with next generation sequencing (NGS)-based technologies.
• Very good knowledge about, and documented practical experience of, work with NGS-based single-cell and spatial biology analyses.
• At least 5 years of practical experience of working with molecular biology methods (e.g. cDNA synthesis, PCR/qPCR, RNA/DNA analysis)
• Very good oral and written communication skills in English

Great emphasis will be placed on personal suitability. You must have a good ability to quickly familiarize yourself with new methods and establish new protocols. You must also have excellent communication and collaboration skills as well as be able to conduct your work independently and with high quality while meeting set deadlines. Finally, you must demonstrate excellent planning, organizational and prioritization skills.

Additional merits for the position are:

• Experience in NGS library preparation (e.g. Illumina DNA Prep, Nextera XT, DLP+)
• Experience in Illumina sequencing (e.g. NextSeq2000, NovaSeq 6000, NovaSeq X Plus)
• Experience from commercially available single-cell analysis platforms (e.g. 10X Chromium, inDrop, ParseBiosciences, Singleron)
• Experience in cell culture of primary cells and cell lines
• Experience in cell or nucleus isolation via flow cytometry
• Experience within histological tissue analysis and fluorescence microscopy
• Experience in tissue sectioning as well as tissue preservation and preparation for histological analysis
• Experience within protein analysis using mass spectrometry
• Experience with long-read sequencing technologies and related data analysis
• Experience with automation of lab procedures and liquid handling systems
• Previous project management experience
• Good oral and written communication skills in Swedish