Lunds universitet, Med fak, Institutionen för laboratoriemedicin

Lunds universitet grundades 1666 och rankas återkommande som ett av världens 100 främsta lärosäten. Här finns 40 000 studenter och 7 600 medarbetare i Lund, Helsingborg och Malmö. Vi förenas i vår strävan att förstå, förklara och förbättra vår värld och människors villkor.

Medicinska fakulteten är ett verksamhetsområde inom Lunds universitet, med ansvar för utbildning och forskning inom medicin, vård och hälsa. Utbildningen sker i nära samverkan med sjukvården och är väl förankrad i fakultetens starka forskningstradition. Fakultetens forskning spänner över ett brett fält inom experimentell grundforskning, patientnära klinisk forskning och hälsovetenskaplig forskning. Medicinska fakulteten, med drygt 1800 anställda och 2700 studenter i Lund, Malmö och Helsingborg, är en kunskapsintensiv mötesplats för studenter, lärare och forskare från hela världen.

Institutionen för laboratoriemedicin (ILM) är en av sex institutioner vid Medicinska fakulteten. Vi bedriver ledande forskning inom det laboratoriemedicinska fältet med fokus på hur sjukdomar uppkommer och hur vi kan förbättra patienters diagnostik och behandling. Några av våra starkaste områden med forskning i världsklass, handlar om cancer-, genetik- och blodforskning.

CanFaster, an EU Horizon 2020 Marie Skłodowska-Curie COFUND programme, is a four-year doctoral program, within cancer research and entrepreneurship. The goal is to faster forward the discoveries in cancer research, to speed up the time from discovery to clinical practice. The candidate will undertake a comprehensive training programme, that includes courses in entrepreneurship, innovation processes, as well as education in clinical aspects of cancer and attend seminar series at the business incubator. Team activities will ensure the development of a network that lasts beyond the programme, and that helps to boost the future career. The CanFaster students will be offered secondments in the non-academic sector, such as clinic or industry. The goal of CanFaster is to educate tomorrow’s cancer researchers in a broad set of scientific, transferable, and business skills to become entrepreneurs and build an international network by the end of the training. The program is administrated by CREATE Health, located in the energetic and dynamic science park, Medicon Village, and the research will be conducted at Faculty of Engineering, Faculty of Medicine, as well as Social Sciences at Lund University in Sweden. Lund University and the Medicon Valley area has been nominated as one of the top 13 Brain belts in life science in the world. http://www.createhealth.lth.se/research/canfaster/

 The PhD student project is entitled:  The role of microRNAs in Homing and Seeding of Prostate Cancer Metastases in Bone. The overall aim of this project is to increase the understanding of cancer metastasis in order to address the unmet clinical need for novel therapeutic strategies targeting metastatic prostate cancer. The development of metastases is a complex, dynamic and inefficient process, involving detachment of the tumour cells from the primary site, entering and surviving in the bloodstream, migration to distant locations, extravasation and establishment at distant sites. These steps are dependent on interaction between the tumour cell and the microenvironment leading to cellular plasticity. Extracellular vesicles containing tumour-derived miRNAs can significantly impact the plasticity of other tumour cells and also effect the cells present in the distant microenvironment priming the metastatic niche as well as subvert the immune cells drive.

The specific aim of this project is to investigate the role of miRNAs in the communication between tumour cells and cells in the bone microenvironment and how this enables homing and seeding of prostate cancer cells in bone environment. The student will study how miRNAs in extracellular vesicles secreted by tumour cells and cells in the bone microenvironment can facilitate priming of the metastatic niche, the survival and expansion of tumour cells in the bone environment, and thus contribute to the metastatic process. This will be studied in vitro using reporter systems and functional cell based assays as well as in vivo imaging in mouse models to elucidate the mechanisms of action. All findings will be validated in clinical material. This project aim to increase the understanding of cancer metastasis and as the reversibility of this type of regulation presents a therapeutic interference option, it can lead to improved design of novel therapeutic strategies to target the metastatic spread.

***

Work duties

The main duties of doctoral students are to devote themselves to their research studies which includes participating in research projects and third cycle courses.

Admission requirements

A person meets the general admission requirements for third-cycle courses and study programmes if he or she:

  • has been awarded a second-cycle qualification, or
  • has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second cycle, or
  • has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Additional requirements

  • Very good oral and written proficiency in English.
  • To qualify for this third cycle program the applicant must have performed an independent research project
  • The applicant must be a highly ambitious scientist with a documented cancer research interest.
  • Outstanding, documented experience in molecular and cell biology

Meriting

  • Experience working with microRNAs
  • Completed FELASA certification for work with animal research and other completed courses in mouse models of cancer
  • Prior experience in RNA sequencing
  • Bioinformatic skills

Assessment criteria

Selection for third-cycle studies is based on the student’s potential to profit from such studies. The assessment of potential is made primarily on the basis of academic results from the first and second cycle. Special attention is paid to the following:

1) Knowledge and skills relevant to the thesis project and the subject of study

2) An assessment of ability to work independently and to formulate and tackle research problems

3) Written and oral communication skills

4) Other experience relevant to the third-cycle studies, e.g. professional experience

Other assessment criteria

1) Motivation to be accepted to the program and statement of career development benefits after graduation from the program

2) The ability to work independently and to formulate and tackle research problems will be judge on based on undergraduate research experiences, a Master's thesis or in a discussion of scientific problems during a possible interview

3) The ability to collaborate and communicate will be judge through the application documents and interview 

4) Mobility, you cannot have resided in Sweden for more than 12 months in the last 3 years 

Consideration will also be given to good collaborative skills, drive and independence, and how the applicant, through experience and skills, is deemed to have the abilities necessary for successfully completing the third cycle programme.

Terms of employment

Third cycle studies at the medical faculty consist of full-time studies for 4 years. Doctoral studentships are regulated in the Higher Education Ordinance (1993:100), chapter 5, 1-7 §§. 

Instructions on how to apply

Applications shall be written in English and include a cover letter stating the reasons why you are interested in the position and in what way the research project corresponds to your interests and educational background. The application must also contain a CV, degree certificate or equivalent, and other documents you wish to be considered.

  • Scanned copies of the complete (Bachelor and Master equivalent) and official academic transcripts in English
  • References: Two reference letters written in the template found at www.canfaster.se. The form should be sent to canfaster@immun.lth.se with the subject Referee form and name of the applicant before the 25th of January 2019.
  • Scanned copy of standardized test results (GRE, TOEFL, etc.).
  • All required application material, including letters of reference, must be complete and submitted by deadline in order for the application to be considered. Documents written in other languages must be translated into English by an authorised translator.
  • You will be asked to answer a number of evaluation questions when submitting the application.

Eligible applicants will be evaluated by an evaluation panel based on merit, motivation to apply to the program, motivation for career development, measured in terms of the academic record, academic excellence, and personal qualifications such as collaboration and communication abilities. The applications will be evaluated continuously and can be contacted for interview prior to the call closure.

Type of employment:                                 Temporary position longer than 6 months

Salary:                                                       Monthly salary, fixed

Number of positions:                                 1

Working hours:                                          100%

Starting date:                                             Spring 2019, according to agreement

City:                                                          Lund

Country:                                                    Sweden

Last application date:                                 2019-01-25



Behörighet

Grundläggande behörighet till utbildning på forskarnivå har den som har: avlagt examen på avancerad nivå, fullgjort kursfordringar om minst 240 högskolepoäng, varav minst 60 högskolepoäng på avancerad nivå, eller på något annat sätt inom eller utom landet förvärvat i huvudsak motsvarande kunskaper.

Bedömningsgrund

Bestämmelser för anställning som doktorand återfinns i förordning SFS 1998:80. Som innehavare får enbart förordnas den som är antagen till utbildning på forskarnivå. Vid tillsättning skall avseende främst fästas vid graden av förmåga att tillgodogöra sig forskarutbildningen. Förutom skyldighet att ägna sig åt egen forskarutbildning kan innehavaren åläggas att fullgöra tjänstgöring som avser utbildning, forskning och administrativt arbete enligt särskilda bestämmelser i förordningen.

Villkor

Tidsbegränsad anställning fyra år enligt HF 5 kap 7§.

 

Anställningsform Visstidsanställning längre än 6 månader
Tillträde Spring 2019, according to agreement
Löneform Månadslön
Antal lediga befattningar 1
Sysselsättningsgrad 100
Ort Lund
Län Skåne län
Land Sverige
Referensnummer PA2018/4531
Kontakt
  • Yvonne Ceder, +46462226452
Facklig företrädare
  • OFR/ST:Fackförbundet ST:s kansli, 046-222 93 62
  • SACO:Saco-s-rådet vid Lunds universitet, 046-222 93 64
  • SEKO: Seko Civil, 046-222 93 66
Publicerat 2018-12-21
Sista ansökningsdag 2019-01-25

Tillbaka till lediga jobb