Doctoral student in physical chemistry - Hiring in process/Finished, not possible to apply

We announce one to two PhD positions within a research program called CASCADE -
Cause or Consequence in Alzheimer's disease (www.cascade.nu).

You will be part of a collaborative network of students and researchers at the Divisions of Physical Chemistry (http://www.fkem1.lu.se) and Biochemistry and Structural Biology (http://www.cmps.lu.se/biostruct/) at Lund University as well as Neurochemistry at
Gothenburg University. The team of supervisors include Emma Sparr, Sara Snogerup Linse, Henrik Zetterberg and Jörg Hanrieder.

Job description

The project aims to study solubility of amyloid beta peptide as a function of intrinsic and
extrinsic factors. The overarching goal addresses whether a change in peptide solubility is a cause or consequence of Alzheimer's disease. The students will use a top-down approach to study to what extent Aβ solubility is modulated by neurochemical factors. ln
parallel, a bottom-up approach will be used to systematically investigate the influence of
molecular factors such as pH, salt, temperature, co-solvents and lipids as well as peptide
sequence variants. Another aim is to reveal to structure of soluble peptide complexes and aggregates formed in vitro and seeded with brain material. To address these scientific questions, we plan to use several state-of-the art methodologies, including optical spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, scattering techniques, fluorescence microscopy, and electron microscopy.

Qualifications

You need a Master degree, or equivalent, with focus on physical chemistry, biophysical
chemistry or equivalent, including advanced level courses in soft matter, surface- and
colloid chemistry, biophysical chemistry or equivalent.

Documented experience of scientific experimental studies of proteins and knowledge in
one or several of the experimental methods mentioned above is an advantage.
Documented excellent level of English (understanding, speaking, writing) is essential.
Excellent communication and presentation skills are also essential. The candidate should
have the ability to work in a team and collaborate with people from complementary
disciplines.

Documents to include with the application: A cover letter 1/2 - 1 page) expressing a
motivation for why you wish to perform a PhD education in physical chemistry at Lund
University, and how the present research project matches your own research interests
and scientific background.

Eligibility
Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment
Limit of tenure, four years according to HF 5 kap 7§.