Postdoctor in in hematopoiesis/regenerative medicine - Hiring in process/Finished, not possible to apply

The Department of Clinical Sciences Lund is one of six departments at the Faculty of Medicine. Clinical Sciences Lund cooperates closely with Skåne University Hospital and the Faculty of Medicine in order to optimize the conditions for preclinical and clinical translational research, research strategies and development, as well as education on both undergraduate and postgraduate levels.

Within the department we aim to maintain a good working environment based on mutual respect and consideration. We constantly strive to improve the conditions for work, development and participation for all employees.

The Laboratory for Cell, Tissue and Organ Engineering
The successful candidate will be part of the novel laboratory for Cell, Tissue and Organ engineering. The laboratory is part of the Wallenberg Centre for Molecular Medicine (WCMM LU), at the Lund Faculty of Medicine (https://www.med.lu.se/english). Focusing on regenerative medicine (regeneration, replacement and repair), WCMM LU is part of a national effort to strengthen Sweden as a world-leading life science nation (https://www.med.lu.se/wcmm).

Our lab aims at deciphering the cellular & molecular mechanisms occurring during phases of bone formation/repair. Using state-of-the-art 3D culture systems, death-inducible human mesenchymal lines and tissue engineering protocols, we focus on studying processes of cartilage/bone/bone marrow establishment in human(ized) contexts. Compiled knowledge will be used for the design of cell-based but cell-free extracellular matrices, to be used as smart-materials for skeletal/hematopoietic repair. As such, the lab covers both fundamental and translation research aspects. The lab is located within the Biomedical Center of the Faculty of Medicine and is part of Lund University (Sweden). More information available on our website: www.bourginelab.com.

We are recruiting highly motivated young scientist at the Post-doctoral level. Applicants with an international research experience and strong background in hematopoiesis/mesenchymal stem cells are encouraged to apply. You will be most welcome in a young, friendly and dynamic environment. The employment as postdoctor is a temporary employment for 24 months with suggested starting date May 1st, 2020 or upon agreement.

Work assignments
The candidate will design novel human mesenchymal cell lines expressing key genes of interest and coordinate associated projects. These cells will be characterized and exploited for the generation of “humanized ossicles”, as in vivo model of human hematopoiesis. The candidate will exploit the models for studying both healthy and malignant human hematopoietic materials, as well as solid tumor metastasis.

Qualifications
Appointment to a post-doctoral position requires that the applicant has a PhD, or an international degreedeemed equivalent to a PhD, within the subject of the position, completed no more than three yearsbefore the last date for applications. Under special circumstances, the doctoral degree can have beencompleted earlier.

Qualifications required:

• PhD degree within the field of Biology, Medicine or Biotechnology.
• Strong experience in cell and molecular biology (RNA and protein analysis), in particular using human mesenchymal and hematopoietic cells.
• Solid knowledge in the bone marrow niche organization and function and experience in 2D/3D cell culture techniques.
• You have already exploited “humanized ossicles” approaches. The laboratory will offer you robust training in human cellular biology, engineering of human cells/tissues/organs, as well as in manipulation of 3D culture systems.
• Ability to work with animals and a past-experience in mouse/humanbone formation, hematopoiesis or developmental biology is required.
• Excellent speaking/writing English levels is necessary.

Desirable skills:

• Strong experience with cellular biology techniques, flow cytometry, 2D/3D cell culture.
• Experience with leukemic patient samples is a plus.
• Knowledge on Good Manufacturing Practices (GMPs) and Standard Operating Procedures (SOPs) is a strong asset.